Abstract In this paper diethoxy-acrylamide methoxyl thiophosphate (DAMT) was synthesized with the reaction N-hydroxymethyl acrylamide and O, O-diethyl phosphorochloridothioate catalyzed by cuprous chloride in presence of triethylamine, and the flame retarded poly (DAMT-co-acrylonitrile) was obtained though free-radically copolymerized process. The properties of copolymer were estimated by Limiting Oxygen Index (LOI) values and thermogravimetric analysis (TGA). The results showed that the LOI value of copolymer with 20 wt% percentage of DAMT coule reach 27vol%.
Keywords: Diethoxy-acrylamide methoxyl thiophosphate, Polyacrylonitrile, Flame retardants, Thermal analysis, Limiting Oxygen Index
Polyacrylonitrile (PAN) is widely used in many aspects because it is easily processed into products of various shape with well flexibility and retention at break to meet the requirements of versatile and advanced applications. However, the combustion of PAN is very easy when it is ignited, which makes it difficult to be used in some ways. Thus, the flame retardant PAN is required …
Abstract Based ON The Crystal Structure of of Imatinib and tyrosine kinase Complex (the PDB ID: 2HYY)., The Active Structure and pharmacophores of Imatinib, and The Interaction BETWEEN Imatinib and The Active Site of tyrosine kinase have have been Explored It WAS found that The methylpiperazin Group In imatinib bound to the active site of tyrosine kinase weaker than other substructure, and there are no important pharmacophores, so this part structure of imatinib can be rebuilt. Further molecular design of anti-cancer drug imatinib’s analogues was carried out by De Novo Drug Design Method, 199 molecules were obtained at first, and 10 molecules with high score were screened by docking software, this research results shows that imatinib ‘s analogues with potential for effective tyrosine kinase inhibitors.
KeyWords anti-cancer drug; imatinib; analogue; De Novo drug design
Initio Molecular Design of Antitumor Drugs Imatinib Derivatives
Abstract In this paper, the structure of tyrosine …
Gao Jungang, Liu Zhanli, Liu Pengyan, Jiang Ning
(College of Chemistry and Environmental Science, Baoding 071002,China)
Received Dec. 10, 2006.
Abstract Molecular imprinted polymers (MIPs) for ciprofloxacin were synthesized using methacrylic acid as a functional monomer and trimethylolpropane trimethacrylate(TRIM) as a cross-linker. The binding property and recognition selectivity were studied by equilibrium binding test. The MIP showed high selectivity and specificity to ciprofloxacin, separation factor a=2.03. Scatachard analysis indicated that two kinds of sites were formed in MIP for ciprofloxacin and the imprinting mechanism was discussed.
Keywords molecularly imprinted polymer；Ciprofloxacin；Molecular recognition
Molecularly imprinted polymers (MIPs) are produced by forming a polymer around a molecule that is used as a template (print molecule). After removal of the print molecule, the polymer can be used as a selective binding medium for the print molecule or structurally related compounds. MIPs have been made selective for a large variety of compounds and have
Abstract A new method was described for simultaneous determination of ciprofloxacin (CIP), ofloxacin (OFL) and norfloxacin (NOR) by capillary electrophoresis with a diode array detector at 280 nm. The separation conditions were investigated and optimized. A new medium, 30 mM sodium tetraborate buffer solution and 22 mM sodium dodecyl sulphate containing 5% (v/v) methanol (pH 8.7), was developed for the complete separation of the three quinolones. The excipients do not affect to separation and analysis. Calibration curves between peak area and concentration in the range 10-1000 mg/L for each compound have good linearity with a correlation coefficient (r) of greater than 0.999, and the detection limit£¨s/n£© was 7.90 mg/L for CIP£¬7.92 mg/L for OFL and 7.56 mg/L for NOR. This method has been successfully applied for simultaneous determination of CIP, OFL and NOR in the pharmaceutical preparations with rapid, accurate, and simple characteristics.
Keywords Capillary electrophoresis; Ciprofloxacin; Ofloxacin; …