Synthesis and characterization of Fire retarded poly (DAMT -co-acrylonitrile)

Abstract In this paper diethoxy-acrylamide methoxyl thiophosphate (DAMT) was synthesized with the reaction N-hydroxymethyl acrylamide and O, O-diethyl phosphorochloridothioate catalyzed by cuprous chloride in presence of triethylamine, and the flame retarded poly (DAMT-co-acrylonitrile) was obtained though free-radically copolymerized process. The properties of copolymer were estimated by Limiting Oxygen Index (LOI) values and thermogravimetric analysis (TGA). The results showed that the LOI value of copolymer with 20 wt% percentage of DAMT coule reach 27vol%.
Keywords: Diethoxy-acrylamide methoxyl thiophosphate, Polyacrylonitrile, Flame retardants, Thermal analysis, Limiting Oxygen Index

Polyacrylonitrile (PAN) is widely used in many aspects because it is easily processed into products of various shape with well flexibility and retention at break to meet the requirements of versatile and advanced applications. However, the combustion of PAN is very easy when it is ignited, which makes it difficult to be used in some ways. Thus, the flame retardant PAN is required …

De Novo drug design of anti-cancer drug imatinib’s analogues

Abstract Based ON The Crystal Structure of of Imatinib and tyrosine kinase Complex (the PDB ID: 2HYY)., The Active Structure and pharmacophores of Imatinib, and The Interaction BETWEEN Imatinib and The Active Site of tyrosine kinase have have been Explored It WAS found that The methylpiperazin Group In imatinib bound to the active site of tyrosine kinase weaker than other substructure, and there are no important pharmacophores, so this part structure of imatinib can be rebuilt. Further molecular design of anti-cancer drug imatinib’s analogues was carried out by De Novo Drug Design Method, 199 molecules were obtained at first, and 10 molecules with high score were screened by docking software, this research results shows that imatinib ‘s analogues with potential for effective tyrosine kinase inhibitors.
KeyWords anti-cancer drug; imatinib; analogue; De Novo drug design

Initio Molecular Design of Antitumor Drugs Imatinib Derivatives

Abstract In this paper, the structure of tyrosine

Pinacolization of Aromatic Aldehydes using Zn


Zang Hongjun, Li Jitai#, Bian Yanjiang#, Li Tongshuang#
(Research Institute of Elemento-organic Chemistry, Key Labortary of Elemento-organic Chemistry, Nankai University, Tianjin.300071; #College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China)

Received Sep.28, 2002. The project was supported by NSFC (29872011), Educational Ministry of China and Educational Department of Hebei Province; Natural Science Foundation of Hebei Province supported the project.

Abstract The coupling reaction of aromatic aldehydes leading to pinacols were carried out by using Zn/montmorillonite K10-ZnCl2 in 50% aqueous THF under ultrasound with 23-87% yield.
Keywords pinacolization, aromatic aldehyde, ultrasound


1,2Diols are very useful synthons for a variety of organic syntheses[1]. They can be used as intermediates for the preparation of ketones and alkenes. More importantly, the pinacol coupling has been applied to the synthesis of biologically active natural compounds[2].
The …