Determination of resorcinol on glassy carbon electrode modified by carbon nanotube and its application in wastewater analysis

Abstract about interesting chemistry news articles for adsorptive stripping method for the determination of resorcinol on multi-walled carbon nanotube modified glassy carbon electrode (MWNT-GCE) was developed. Cyclic voltammetry was used in the study of the electrochemical behavior of resorcinol on MWNT-GCE. The sharp peak of resorcinol appeared at 0.6 V (vs. Ag/AgCl) with the differential pulse voltammetry (DPV). The experimental parameters were optimized. Anodic peak currents were linear over the resorcinol concentrations in the range of 5.5×10-5-3.3×10-3 g L-1 with a detection limit of 1.1×10-5 g L-1 and relative standard deviations of 3.30-6.94% for 7 determinations. The interference of organic and inorganic species on the voltammetric response was also tested. The proposed method was applied to the determination of resorcinol in tap water and simulative wastewater samples with an average recovery of 95.2-104.8%.
Keywords Determination; Carbon nanotube; Modified glassy carbon electrode; Differential pulse …

Synthesis and characterization of Fire retarded poly (DAMT -co-acrylonitrile)

Abstract In this paper diethoxy-acrylamide methoxyl thiophosphate (DAMT) was synthesized with the reaction N-hydroxymethyl acrylamide and O, O-diethyl phosphorochloridothioate catalyzed by cuprous chloride in presence of triethylamine, and the flame retarded poly (DAMT-co-acrylonitrile) was obtained though free-radically copolymerized process. The properties of copolymer were estimated by Limiting Oxygen Index (LOI) values and thermogravimetric analysis (TGA). The results showed that the LOI value of copolymer with 20 wt% percentage of DAMT coule reach 27vol%.
Keywords: Diethoxy-acrylamide methoxyl thiophosphate, Polyacrylonitrile, Flame retardants, Thermal analysis, Limiting Oxygen Index

1 INTRODUCTION
Polyacrylonitrile (PAN) is widely used in many aspects because it is easily processed into products of various shape with well flexibility and retention at break to meet the requirements of versatile and advanced applications. However, the combustion of PAN is very easy when it is ignited, which makes it difficult to be used in some ways. Thus, the flame retardant PAN is required …

De Novo drug design of anti-cancer drug imatinib’s analogues

Abstract Based ON The Crystal Structure of of Imatinib and tyrosine kinase Complex (the PDB ID: 2HYY)., The Active Structure and pharmacophores of Imatinib, and The Interaction BETWEEN Imatinib and The Active Site of tyrosine kinase have have been Explored It WAS found that The methylpiperazin Group In imatinib bound to the active site of tyrosine kinase weaker than other substructure, and there are no important pharmacophores, so this part structure of imatinib can be rebuilt. Further molecular design of anti-cancer drug imatinib’s analogues was carried out by De Novo Drug Design Method, 199 molecules were obtained at first, and 10 molecules with high score were screened by docking software, this research results shows that imatinib ‘s analogues with potential for effective tyrosine kinase inhibitors.
KeyWords anti-cancer drug; imatinib; analogue; De Novo drug design

Initio Molecular Design of Antitumor Drugs Imatinib Derivatives

Abstract In this paper, the structure of tyrosine

Pinacolization of Aromatic Aldehydes using Zn

zn

Zang Hongjun, Li Jitai#, Bian Yanjiang#, Li Tongshuang#
(Research Institute of Elemento-organic Chemistry, Key Labortary of Elemento-organic Chemistry, Nankai University, Tianjin.300071; #College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China)

Received Sep.28, 2002. The project was supported by NSFC (29872011), Educational Ministry of China and Educational Department of Hebei Province; Natural Science Foundation of Hebei Province supported the project.

Abstract The coupling reaction of aromatic aldehydes leading to pinacols were carried out by using Zn/montmorillonite K10-ZnCl2 in 50% aqueous THF under ultrasound with 23-87% yield.
Keywords pinacolization, aromatic aldehyde, ultrasound

1 INTRODUCTION

1,2Diols are very useful synthons for a variety of organic syntheses[1]. They can be used as intermediates for the preparation of ketones and alkenes. More importantly, the pinacol coupling has been applied to the synthesis of biologically active natural compounds[2].
The …

Preparation of MAA/TRIM molecularly imprinted polymers and binding selectivity for ciprofloxacin

Gao Jungang, Liu Zhanli, Liu Pengyan, Jiang Ning
(College of Chemistry and Environmental Science, Baoding 071002,China)

Received Dec. 10, 2006.

Abstract  Molecular imprinted polymers (MIPs) for ciprofloxacin were synthesized using methacrylic acid as a functional monomer and trimethylolpropane trimethacrylate(TRIM) as a cross-linker. The binding property and recognition selectivity were studied by equilibrium binding test. The MIP showed high selectivity and specificity to ciprofloxacin, separation factor a=2.03. Scatachard analysis indicated that two kinds of sites were formed in MIP for ciprofloxacin and the imprinting mechanism was discussed.
Keywords  molecularly imprinted polymer;Ciprofloxacin;Molecular recognition

  1. INTRODUCTION
    Molecularly imprinted polymers (MIPs) are produced by forming a polymer around a molecule that is used as a template (print molecule). After removal of the print molecule, the polymer can be used as a selective binding medium for the print molecule or structurally related compounds. MIPs have been made selective for a large variety of compounds and have

Simultaneous determination of ciprofloxacin, ofloxacin and norfloxacin in pharmaceutical preparations by capillary electrophoresis

Abstract A new method was described for simultaneous determination of ciprofloxacin (CIP), ofloxacin (OFL) and norfloxacin (NOR) by capillary electrophoresis with a diode array detector at 280 nm. The separation conditions were investigated and optimized. A new medium, 30 mM sodium tetraborate buffer solution and 22 mM sodium dodecyl sulphate containing 5% (v/v) methanol (pH 8.7), was developed for the complete separation of the three quinolones. The excipients do not affect to separation and analysis. Calibration curves between peak area and concentration in the range 10-1000 mg/L for each compound have good linearity with a correlation coefficient (r) of greater than 0.999, and the detection limit£¨s/n£© was 7.90 mg/L for CIP£¬7.92 mg/L for OFL and 7.56 mg/L for NOR. This method has been successfully applied for simultaneous determination of CIP, OFL and NOR in the pharmaceutical preparations with rapid, accurate, and simple characteristics.
Keywords Capillary electrophoresis; Ciprofloxacin; Ofloxacin; …

Determination of Tanshinone IIA in two kinds of Chinese traditional patent medicines by HPLC

Abstract A HPLC method for the determination of Tanshinone IIA in the Dan Qi Pian and Tong Mai Chongji was established. The sample was dissolved in methanol and extracted by ultrasound, then chromatographed on LUNA-C18 column with mobile phase of methanol-water (84:16). The flow rate was set at 0.8mL/min and the detection wavelenghth was of 270nm. This HPLC method is simple, rapid and accurate, it can be used to determine Tanshinone IIA in the Dan Qi Pian and Tong Mai Chongji quantitatively .
Keywords Tanshinone IIA, Dan Qi Pian, Tong Mai Chongji, HPLC

Dan Qi Pian and Tong Mai Chongji are general Chinese traditional patent medicines. Although they are edited in the eighth volume(1993) of Medicine Standards published by the Ministry of Health of the Peoples Republic of China, there was not any determination method for their effective components. Hence it was difficult to examine the quality …